Professor Yiannis Ventikos, University College London

Multiscale Modelling of transport Phenomena in the Brain: From Ventricles to Aquaporins
When Jun 15, 2015
from 02:00 PM to 03:00 PM
Contact Name
Contact Phone 01865-273925
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The human brain is the most important organ in body and the most complex entity we know of. Its great importance has resulted in a number of unique features, as it evolved to the centre of cognitive function it is: it has extreme metabolic and oxygenation needs but with minimal capacity to store glucose and oxygen; it is perfused by a markedly complex vascular system, it produces and floats in cerebrospinal fluid which is in continuous exchange with vascular plasma and – enclosed in a rig cavity, the cranium – is probably the most inaccessible organ in the body. This combination of conditions results in a particularly complex environment where transport phenomena play a predominant role in the organ’s homeostasis. We propose a novel multi-scale approach for addressing these challenges, that involves the representation of cerebral tissue as a porous elastic medium permeated by a multiplicity of passages – each with its own features (porosity, permeability etc.) These networks have the potential to communicate with each other, according to predefined transport laws; for example the cerebrospinal fluid compartment can receive liquid from the arterioles/capillaries compartment and can drain in the venal compartment. We apply this new modelling framework to certain conditions and examine its efficacy in enhancing our understanding of cerebral disease.