Prof Cathy Ye, Oxford Engineering Science (IBME)

Biomaterials for tissue engineering applications
When Feb 15, 2016
from 02:00 PM to 03:00 PM
Where LR8
Contact Name
Contact Phone 01865-273925
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To be able to culture cells in 3D, suitable extracellular matrix (ECM) are required to facilitate cell adhesion, growth, migration and differentiation (for stem cells). Different cell types may require ECM of different properties including composition, stiffness, surface properties, pore size, porosity and etc. One of the techniques established in the group, electrospinning, has been used to produce very fine fibres (diameters from hundreds of nano meters to several microns) of natural proteins and synthetic polymers. These fibres are a close mimic of the natural fibrous ECM in vivo in terms of dimensions and arrangement. Hydrogels are another category of biomaterials used to mimic ECM. These are jelly-like materials with high water content and they can have properties ranging from soft and weak to hard and tough based on the degree of cross-linking. Commonly used ones for cell culture are collagen, alginate, chitosan and hyaluronan.